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The complete selection process, including the number of records identified, screened, and excluded with explicit reasons (separated for preclinical and clinical/epidemiological literature), is documented in the PRISMA flow diagram (Figure 1)

311,981,984 Combining the calcium channel blocker amlodipine with iron chelation therapy may enhance the efficacy of iron chelation, and provide a novel strategy for preventing and treating cardiac iron overload in patients with thalassemia