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Weight Loss Thresholds 5% weight loss: 81.8% of tirzepatide patients achieved this versus 66.5% of semaglutide patients (hazard ratio 1.76) 10% weight loss: 62.1% versus 37.1% (hazard ratio 2.54) 15% weight loss: 42.3% versus 18.1% (hazard ratio 3.24) The Gap Widens Over Time The absolute difference in weight reduction grows the longer patients stay on treatment: At 3 months: an additional 2.4% weight loss with tirzepatide At 6 months: the gap widens to 4.3% At 12 months: tirzepatide shows a 6.9% greater absolute reduction in body weight Notably, weight loss outcomes tend to be more pronounced in patients without Type 2 Diabetes, regardless of which medication is used a difference attributed to underlying metabolic factors still under investigation