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Weizer-SternOAdamskyKAmariglioNRachmilewitzEBredaLRivellaSet alMrna expression of iron regulatory genes in Beta-thalassemia Intermedia and Beta-thalassemia Major mouse models

The combination of deferiprone (an iron chelator) and N-acetylcysteine (an antioxidant) has been reported to enhance cardiac calcium homeostasis and reduce oxidative stress in iron-overloaded thalassemic mice (86)

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When combining modalities, some practitioners suggest the cryotherapy component may allow for lower BPC-157 doses while achieving equivalent outcomes