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A 2024 network meta-analysis published in Metabolism , which reviewed 27 randomized controlled trials and over 15,500 patients with obesity or overweight, confirmed that GLP-1 receptor agonists produce significant weight loss and waist circumference reduction across multiple formulations

Patients with certain GLP1R or GIPR variants may experience faster onset or more pronounced nausea, while others adapt more gradually

However, approval typically requires prior authorization and clinical criteria