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Description

Glutathione reductase reduces GSSG to GSH at the expense of oxidation of NADPH

At low concentrations, it increases MMP1 and MMP2, which break down damaged or disorganized collagen and elastin

Secondary outcomes included the pharmacokinetic profile of PG-102, assessed using serum concentrationtime data and non-compartmental analyses, with exploratory pharmacodynamic and biomarker endpoints

For patients with type 2 diabetes, both interventions can improve glycaemic control, potentially leading to benefits in blood glucose management and HbA1c reduction