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Although the ELIXA studythe only CVD outcome trial of GLP-1 RAs published to datereported a neutral cardiovascular effect of lixisenatide, the potential cardiovascular benefits of GLP-1 RAs should not be overlooked, because high-risk subjects with established CVD were recruited in this study to delineate its cardiovascular safety within a short-term period

Across the evaluated dose pairs, high posterior probabilities of clinical equivalence were observed for semaglutide 2.4 mg versus tirzepatide 10 mg and semaglutide 7.2 mg versus tirzepatide 15 mg, suggesting that similar weight-loss outcomes can be achieved with these dose combinations

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution