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While distinct mechanisms such as miRNA regulation and EVs transfer add complexity, these converging pathways collectively sustain a hazardous cycle of microglial activation, oxidative stress, programmed cell death, and chronic inflammation, ultimately driving neurodegeneration in HAND

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We first tested this in animals treated with the anthracycline chemotherapy drug, doxorubicin (Dox), which is associated with an increased risk of ovarian failure in patients (Green et al, 2009a

Serotonin transporter activity in mouse oocytes is a positive indicator of follicular growth and oocyte maturity