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Searching for Biomarkers in the Blood of Patients at Risk of Developing Parkinsons Disease at the Prodromal Stage

To counter this limitation, a group of GLP-1 receptor agonists (GLP-1RAs), which are resistant to DPP4-mediated degradation [32], have been developed and shown to be effective in treating T2DM and obesity [33]

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Experimental work indicates that statins disturb mitochondrial complexes, although this sits mainly in mechanistic studies rather than patient-level trial In clinic I treat these hypotheses as prompts to focus on whole-mitochondrial support sleep, nutrient-dense diet, physical activity matched to capacity, and careful review of polypharmacy rather than chasing every possible supplement