glp 1 when not overweight Long-term Success of GLP-1s Hinges on More Than Just a Prescription Is GLP-1 the Same as

When contacted for comment, a representative for Novo Nordisk (which makes the semaglutide medications Ozempic, Wegovy, and Rybelsus) told Mens Health via email, Novo Nordisk welcomes independent research investigating the safety, efficacy, and clinical utility of our products

Although we are talking about the same GLP1 molecule, and the same receptor it acts upon, we are potentially considering two substantially different modes of action

Short-acting GLP-1RAs The short-acting exenatide is identical to the exendin-4 structure, while lixisenatide has been modified from exendin-4 (deletion of proline and an addition of six lysine amino acids at the carboxyl terminus) to make them resistant to degradation by DPP-4 without compromising their GLP-1R activating potencies (9)

February 2026