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High epidemiological reliability denotes the strongest available evidence with no indication of significant variance or bias ( (i) Persuasive: statistical significance per the random-effects model of p 1,000 cases, low heterogeneity among the selected studies ( I 2 1,000 cases, and most studies indicating a significant effect

Monitoring recommendations include checking thyroid function tests (TSH and free T4) if you experience significant weight change or develop symptoms suggestive of thyroid dysfunction

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