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Fanfone, D

The hypoxic microenvironment of RA joints can cause reactive oxygen species (ROS) accumulation and mitochondrial damage, which not only affect the metabolic processes of immune cells and pathological changes in fibroblastic synovial cells but also upregulate the expression of several inflammatory pathways, ultimately promoting inflammation

[PMC free article] [PubMed] [Google Scholar] 47.Erba D., Riso P., Bordoni A., Foti P., Biagi P., Testolin G