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33,34 Lower-extremity amputation may be the only choice by the progression of diabetic foot ulcers after the onset of peripheral neuropathy, peripheral arterial disease, and immunosuppression

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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)