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These effects depend on factors such as melatonin receptors, local hormone concentration, type of cellular receptors, and signaling systems [3], according to the phase of the circadian cycle

Song C, Sun S, Wang J et al (2023) Applying fulvic acid for sediment metals remediation: Mechanism, factors, and prospect

Notably, therapies could be designed to target these markers, thus providing a means of eliminating the CSC population, attenuating EMT, and curbing metastasis [207]