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The processed snRNA-seq in AAV- Pcsk5 and AAV-Ctrl mice and bulk RNA sequencing in HUVECs data are available at figshare ( Other previously published patient datasets used in the study can be accessed with the following accession numbers: GSE184986, GSE132143, GSE41166, GSE270788, GSE110209, GSE153481, Figures 2A, G, 8A, D, S3A, and S4A were generated using BioRender under a paid subscription (agreement numbers: AP29BK99A0, SX29G17FUG, YC29H5H18H, IA29H5HWKF, LD29H5HPI5, GI29H5HIIC)