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Dual-agonist compounds such as Tirzepatide add GIP receptor activity on top of the GLP-1 pathway, producing a more pronounced metabolic effect than single-agonist compounds but still without the glucagon-receptor-driven energy expenditure component unique to triple agonists

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An additional third of the EDTA-treated plasma was flash frozen on dry ice and stored at 80 o C without prior deproteinization but was deproteinized upon thawing

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