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Keywords: cardiac muscle, endothelium, GLP-1, insulin resistance, microvascular perfusion, skeletal muscle 1 |

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These activated Smads form a complex with Smad4, which translocates to the nucleus and promotes the expression of pro-fibrotic genes [24], such as Type I Collagen alpha 1 (COL1A1) and Fibronectin and Connective Tissue Growth Factor (CTGF)