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Notably, in murine pancreatic -cells, GLP-1 can activate both G proteins Gs and Gq, whereas GIP selectively activates Gs (45)

In recent years, metformin has attracted broader interest beyond diabetes management, with researchers studying it in the context of longevity and general metabolic health

doi: 10.3389/fendo.2024.1465881 Received 18 July 2024 Accepted 28 August 2024 Published 20 September 2024 Volume 15 - 2024 Edited by Xiaosheng Tan, Rutgers, United States Reviewed by Xiaodong Zou, The Chinese University of Hong Kong, Shenzhen, China Xue Wan, Mayo Clinic, United States Xun Sun, Indiana University, United States Updates Copyright 2024 Ji, He, Min, Yang, Wu, Xu, Chen and Mei

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