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These individuals can benefit from customized training and nutritional plans that support optimal ligament health and repair

Generalizing these findings to healthy adults requires significant caution

This is highly significant, as it reveals that rare mutations in the HRD motifs of protein kinases are highly penetrant and disease-causing, which provides a strong functional rationale for the R311C mutation in the HRD motif of CaMKK2 being considered a potential monogenic model of bipolar 1 disorder