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Systems Biology in Reproductive Medicine

Schwarzer JU, Muhlen B, Schukai O

In addition, the dual InsR/IGF-IR inhibitor linsitinib can prevent the emergence of breast cancer cells that are resistant to long-term estrogen deprivation or antiestrogen treatment and inhibit growth of established ER+ breast cancer xenografts in ovariectomized mice [107]

Your dose also plays a rolelower doses may have less appetite suppression, so you might eat more pizza initially than you will at a higher therapeutic dose