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IV fluids if vomiting prevents oral intake Red-flag threshold / inability to keep any liquids down for more than 24 hours requires same-day clinical evaluation Key electrolytes at risk / sodium, potassium, and chloride can fall with severe or prolonged vomiting and diarrhea Dose relationship / GI side effects peak during dose escalation and often improve after 4-8 weeks at a stable dose Concurrent risk / patients on diuretics, SGLT-2 inhibitors, or ACE inhibitors face compounded dehydration risk Why GLP-1 Drugs Cause Dehydration in the First Place GLP-1 receptor agonists work partly by slowing gastric emptying and acting on brainstem nausea centers