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The peptide also promotes polarization of macrophages from pro-inflammatory M1 phenotypes toward tissue-repairing M2 phenotypes, with treated macrophages showing 70% increased phagocytic activity for clearing inflammatory debris and 3-fold higher production of VEGF compared to untreated controls

The introduction of nanotechnology has further advanced dual strategies that couple physical metabolic disruption with immune activation

It is estimated that more than 50% of the mortality in those patient with end-stage renal disease (ESRD) on dialysis is related to CVD and its complications [62]