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Indeed, c-myc induces the transcription of glutamine transporters, such as SLC1A5/ASCT2, and also promotes the expression of glutamine-catabolized enzymes such as glutaminase 1 (GLS1) and carbamoyl-phosphate synthetase 2 - aspartate transcarbamylase - dihydroorotase (CAD), in order to encourage glutamine uptake by converting glutamine to glutamate [19-21]
doi: 10.1128/spectrum.01730-22 60 FiorentinoGCoppolaAIzzoRAnnunziataABernardoMLombardiAet al
2011;6(3):e18046
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