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When used alone, semaglutide has not been shown to increase the risk of severe hypoglycemia (i.e., glucose levels of 56 mg per dL [3.1 mmol per L] or less) compared with placebo

Albumin Binding as a Pharmacokinetic Determinant of Semaglutide Effects Semaglutide contains a large hydrophobic fatty diacid side chain that anchors the peptide to human serum albumin [66]

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