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Given the non-linear relationship between rehabilitation volumes and outcomes, restricted cubic splines were used

Whether this pattern persists beyond 52 weeks, whether it is dose-dependent, and whether it is reversible upon discontinuation of therapy are questions that remain unanswered and need to be addressed in larger, longer-duration trials

Limitations Adverse Effects Although GLP1-RA help improve glycemic control, promote weight loss, and reduce cardiovascular events, there are several limitations to its use

However, some women experience disrupted sleep during dose escalation phases, particularly if nausea or digestive discomfort interferes with nighttime rest