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A dose-dependent inhibition of cytochrome P450, family 1, subfamily A, polypeptide 1 and cytochrome P450, family 2, subfamily B, polypeptide 1/2 by sulforaphane (SFN) was observed in rat hepatocytes, and also the expression of cytochrome P450, family 3, subfamily A, polypeptide 4 (the major cytochrome P450 enzyme in human liver) was markedly decreased at both mRNA and activity levels ( Reference Maheo, Morel and Langouet 17 )
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