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This metabolic shift enables CSCs to sustain ATP production and enhance survival under harsh conditions, such as stress induced by chemotherapy or radiotherapy

*Correspondence: Hamid Zand, [email protected]

doi: 10.3389/fendo.2022.846903 Received 31 December 2021 Accepted 01 February 2022 Published 21 February 2022 Volume 13 - 2022 Edited by Paolo Moghetti, University of Verona, Italy Reviewed by Flavia Prodam, University of Eastern Piedmont, Italy Updates Copyright 2022 Cignarelli, Genchi, Le Grazie, Caruso, Marrano, Biondi, DOria, Sorice, Natalicchio, Perrini, Laviola and Giorgino

First, let's be clear what we're talking about - what sort of symptoms are we discussing here