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In the present study, we have not only unveiled the interaction of endosomal GLP-1R with the ER, but also its localisation to VAPB-containing ERMCSs, from where the receptor assembles a newly described PKA signalling nanodomain, enabling cAMP-dependent PKA activation at the interface between the ER and mitochondria

Nutrient selection in the absence of taste receptor signaling

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The findings are based on data from Denmark, where researchers analyzed how many new moms filled a prescription for a GLP-1 drug within six months of giving birth