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But this logic doesnt hold up under formulation science

Investigators are developing models to predict the efficacy of DPP-4 inhibitors, GLP-1 RAs, SGLT-2 inhibitors, sulfonylureas, and thiazolidinediones to lower HbA1c levels using widely available clinical features (age, duration of diabetes, sex, baseline HbA1c, BMI, estimated glomerular filtration rate, HDL cholesterol, total cholesterol, and alanine aminotransferase) to facilitate therapy (14)

Schttelkopf AW, van Aalten DMF (2004) PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

The net result is angiogenesis new blood vessels forming at injury sites, bringing oxygen and nutrients right where they're needed