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Although empagliflozin appeared to have less of a reno-protective effect in patients with HFpEF than with HFrEF, further analyses of EMPEROR-Preserved indicate that this may be related to the endpoint definition used (which excluded renal death and included 40% decrease in eGFR), with positive findings when using the renal endpoint from the DAPA-HF trial (which included renal death and 50% decrease in eGFR) [130, 131]

Therefore, the early recognition and treatment of this condition not only has the potential to prevent the onset of T2D but also to reduce cardiovascular mortality