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That reliance explains why companies invest heavily in indication-specific trials and why, in 2023, GLP-1 medications accounted for 45% of the total diabetes drug market, according to HealthVerity Blog

These studies have highlighted a specific structural feature termed steric zipper, in which the adjacent -sheets are tightly held together with facing side chains interdigitated via an interface devoid of water (Sawaya et al., 2007)