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These drugs helped lower blood sugar through a few specific mechanisms: Increased insulin secretion from the pancreas Reduced how much sugar the liver put into the bloodstream (via reducing glucagon) Slowed gastric emptying, which makes glucose appear slower in the blood stream

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This ERK-without-Akt profile supports cellular proliferation and survival while maintaining cells in a proliferative rather than differentiated state contrasting sharply with IGF-1s PI3K/Akt/mTOR-dominant signalling, which drives protein synthesis and differentiation