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23 However, their use is limited by anticholinergic side effects, especially in elderly patients and those with cardiovascular disease

A study that examined the effect of carnosine on oxidative stress in human kidney tubular epithelial (HK2) cells indicated that carnosine decreased NADPH oxidase (Nox) 4 expression and increased total superoxide dismutase (T-SOD) activity, thus reducing the production of intracellular ROS, relieving the oxidative stress of cells, and ultimately inhibiting the mitochondrial pathway of apoptosis [100]

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BPC-157 is unusually stable in human gastric juice for a peptide, which is why oral and capsule formats appear in research planning, especially for gut models