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Copper toxicity: the biggest concern is shown in an accumulation of Copper in the bloodstream, particularly with individuals who have preexisting diseases such as Wilson's disease

Vitamin B-12 supports an array of bodily functions with its water-soluble nutrient structure

Environmental stressors further modulated susceptibility: high ammonia levels damaged mucosal barriers and impaired tight junctions 107 , while thermal stress activated the hypothalamicpituitaryadrenal axis, inducing stress-related immunosuppression and weakening respiratory mucosal defense 108

These chronic attributes are generally associated with selective degeneration of dopaminergic neurons, corollary de-pigmentation of substantia nigra pars compacta (SNpc) and concomitant accumulation of -synuclein in insoluble inclusions called Lewy bodies 2,3