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TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development

The medications also suppress hunger and slow the digestion process, leading patients to feel full on smaller portions or for longer periods of time after eating

Comparison with other antidiabetic medicines like insulin, metformin, sulfonylureas, thiazolidinediones, -glucosidase inhibitors placebo showed no statistically significant increase in fracture risk for DPP-4i, GLP-1 RAs, or SGLT-2i

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