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Additionally, some earlier NMA studies that compared the treatment effects of GLP-1RA and TZD have presented mixed results

The compounded semaglutide dose chart and the compounded semaglutide guide discuss how individual responses inform dosing decisions

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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation