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Mechanisms underlying cardiac protection include enhanced coronary angiogenesis, antioxidant effects reducing oxidative damage, anti-inflammatory modulation limiting inflammatory cell infiltration, and direct cardiomyocyte protection

FSP1/CoQ10/NADPH system FSP1, identified as another ferroptosis suppressor through genome-wide screening, primarily prevents lipid peroxidation and ferroptosis by reducing lipid free radicals in lipid droplets or plasma membranes [112]

Inactivation of GPX4 leads to accumulation of lipid ROS and induces ferroptosis 18,31

This result is associated with an immunomodulatory process (reduced expression of cytokines such as IL-8 and TNF-) ( Lactobacillus fermentum UCO-979C enhances resistance to H