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170 , 178 In those individuals with GS deficiency and oxoprolinemia, administration of oral sodium bicarbonate or citrate is necessary to control acidosis

Using Mendelian randomization and UK Biobank data, researchers found that this biological response signature is causally associated with a significantly lower risk of Ischemic Heart Disease (OR = 0.87) and diabetes (OR = 0.66), cementing berberine's status as a powerful cardioprotective agent

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