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Pharmacodynamic Effects and Duration Despite measurable plasma clearance, pharmacodynamic effects extend well beyond plasma half-life[20]: Weight loss effects continue throughout treatment with no plateau observed within 48-week study periods Glycemic improvements persist between weekly doses with stable glucose control Appetite suppression effects remain consistent throughout dosing intervals Tissue receptor occupancy likely exceeds plasma peptide concentrations This disconnect between pharmacokinetics and pharmacodynamics suggests prolonged receptor engagement, tissue depot effects, or persistent downstream signaling cascade activation

Most significantly, it stimulates insulin production, slows the emptying of food from the stomach, and increases feelings of satiety [3]

Wegovy has shown the largest average weight loss in clinical trials

Effects of GLP-1 and GLP-1 receptor agonists on bone metabolism and bone fracture