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The hospitalization rates among 20 to 54-year olds who are overweight or obese are up to 40% higher

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Stimulated by TNF- and IL-1, RANKL secreted by synovial fibroblasts induces macrophages to transform into osteoclasts ( Another major reason for fibroblast-induced disease in synovial tissue is that these cells are resistant to apoptosis ( Synovial hyperplasia induced by metabolic conversion may originate from signaling