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Second, the underlying molecular processes behind the occurrence of distant metastasis, dormancy, and late-stage disease recurrence, especially in hormone receptor-positive breast cancer, are not fully understood, making it difficult to develop efficient metastasis-preventive therapies (327)

Whether this pathway is involved in SFN induced dephosphorylation of STAT3 remains to be elucidated, but the ROS-mediated regulation of STAT3 may partially connect SFN-treatment to the strongly inhibited T H 17 cell responses on the molecular level

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Expert consensus decision pathway on novel therapies for cardiovascular risk reduction in patients with type 2 diabetes