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Description

Together, these cellular studies highlight multiple convergent mechanisms, namely anti-inflammatory, anti-oxidative, pro-survival, and TGF-/Smad inhibitory, through which incretin receptor agonists may modulate cardiac fibrogenesis

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In preclinical research, doses from 6 g/kg to 20 mg/kg caused no acute organ toxicity, and thorough mutagenicity, genotoxicity, and teratogenicity assays returned negative results

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