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15 , 16 This study synthesizes 21 RCTsincluding the latest CV and renal outcome studiesinvolving nearly 100,000 patients, applies incidence rate ratios (IRRs) to account for variable follow-up, incorporates trial sequential analysis, and provides the most comprehensive pooled evaluation to date of both efficacy and safety in DM and non-DM populations

Mitochondrial dysfunction is considered to play an underlying role in bipolar disorder, and abnormal accumulation of mitochondrial Ca 2+ is a potent trigger of necrosis, apoptosis, and autophagy [15,16,17,18]

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