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Two major Ca 2+ entry pathways are important for NO production: store-operated Ca 2+ entry (SOCE), the main agonist-induced Ca 2+ entry mechanism in ECs (Tran, 2020), and mechanosensitive Ca 2+ entry, stimulated by blood shear stress
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Additionally, some patients may possibly develop nutritional deficiencies particularly in protein, iron, or B vitaminsif their reduced food intake is not nutritionally balanced