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In the feeding state, GH secretion decreases while insulin secretion increases, leading to increased glucose uptake by skeletal muscle and fat accumulation

This drew our attention to the ubiquitin-related protein UBE2m, which is a ubiquitin-conjugating enzyme essential for the neddylation that was significantly enriched (Fig

Histone hyperacetylation in the BDNF (Brain-Derived Neurotrophic Factor) gene, which increases brain-derived neurotrophic factor expression, occurs after an epileptic seizure and is thought to be a neuroprotective mechanism that VPA may enhance or prolong

Keywords: type 2 diabetes, obesity, insulin, glucagon, GLP-1, GLP-1R, incretin, metabolism Introduction Maintaining metabolic homeostasis is essential in all living organisms, as it provides energy in the form of adenosine trisphosphate (ATP) required for cellular processes to proceed