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In the present study, we have not only unveiled the interaction of endosomal GLP-1R with the ER, but also its localisation to VAPB-containing ERMCSs, from where the receptor assembles a newly described PKA signalling nanodomain, enabling cAMP-dependent PKA activation at the interface between the ER and mitochondria

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To learn more about Ozempic face, check out this study from the National Institute of Health.

Then, the BMECs were collected and washed three times with PBS, and quantitative uptake was tested with a FACS Calibur flow cytometer (BD Biosciences, USA)