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The FDA classifies phentermine as a Schedule IV controlled substance due to its stimulant properties and potential for dependence, though actual addiction rates remain low when the medication is used as prescribed

Posteriormente se ha visto que en la mayora de los casos es un fenmeno transitorio, que revierte al suspender la AP, pero en algunos casos puede llegar a fibrosis e insuficiencia heptica, siendo una de las causas de trasplante heptico

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