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In the original 2015 Cell Metabolism paper, MOTS-c activated AMPK, improved insulin sensitivity in diet-induced obese mice, and reduced age-related insulin resistance in older animals [2]

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Rhonda Patrick, a biomedical scientist and founder of FoundMyFitness, emphasizes: "NAD+ levels can go up when we exercise or fast, but NAD+ precursors like NR and NMN boost them further, supporting energy production and cellular repair."[17] She notes that combining lifestyle with supplementation yields optimal results

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