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Experimental work on intestinal anastomosis models and related gastrointestinal injury systems has evaluated endpoints including tissue tensile strength, inflammatory signaling markers, and vascularization within healing intestinal segments

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Thus, the healing of the esophagocutaneous, gastrocutaneous, duodenocutaneous, colocutaneous, vesicovaginalis, and rectovaginalis fistulas, assessed grossly, biomechanically and microscopically means demonstration of the both external and internal fistulas healing and consequently, the realization of the simultaneous healing of different tissues