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When to Talk to a Doctor People taking semaglutide and allergy medications should talk to a doctor if they experience: Severe nausea, vomiting, or diarrhea that makes it hard to take other medications Worsening allergy symptoms despite taking medications High blood pressure, dizziness, or rapid heart rate after using a decongestant Blood sugar changes (for people with diabetes) when using corticosteroids A healthcare provider can help adjust medication doses, recommend alternative treatments, or check for drug interactions