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Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

Early studies and case reports suggest possible benefits in psoriasis, hidradenitis suppurativa, and wound healing

While it cannot selectively target belly fat, research shows that higher growth hormone levels are associated with reduced visceral fat, the deeper fat stored around the organs in the midsection

Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells